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TIM for Pharmaceutical Research

Dynamic in vitro GastroIntestinal model.
A HIGH-END DISSOLUTION AND DIGESTION APPARATUS "TIM"

TIM Technology

The TIM system is used to get reproducible and reliable scientific data about the behavior of your oral drug products during transit through the stomach, the small intestine and large intestine. This Dynamic in vitro gastro intestinal model is able to mimic the GI conditions of humans in different age groups, like adults, infants and elderly, but also various animal conditions like pigs, calf’s and dogs. As a reliable in vitro predictive tool, the TIM systems are an alternative to animal studies and help you reduce the failure rate of time-consuming and expensive human clinical studies. The TIM system contributes to an efficient product development by selecting your most promising candidate aimed for selected populations. Studies can be performed under different GI conditions and health status in a fed or fasted state.
A movie is created to explain the dynamics and possibilities of the model, please click right to view.

System Appearance

サンプルイメージ

Please also visit the TIM company website in the NL   - Link to TIM BV -

Application for Pharmaceutical and Formulation Research

サンプルイメージ

 Assessment of BioAccessibility of API
 Optimization of Control release (IR/SR)
 Comparizon of nano or micro API formulations
 Assessment of Drug-Food/Nutrient Interaction
 Stability of API in GI tract.
  Biological Transformation of API by Intestinal Microflora
 Troubleshooting unexpected results in clinical trials
 Evaluation of low permeability and/or low solubility API (BCS 2, 3, 4)
 Evaluation under different physiological conditions, e.g. infants, adults, elderlies, diseases, animals, etc.

Publication       → □ Download Publication list ver.Nov2020.

European Journal of Pharmaceutics and Biopharmaceutics. 2020
On the usefulness of compendial setups and tiny TIM system in evaluating the in vivo performance of oral drug products with various release profiles in the fasted state:
Case example sodium salt of A6197.

Schilderink, R., Protopappa, M., Fleth‐James, J., Vertzoni, M., Schaefer, K., Havenaar, R., ... & Reppas, C.

PloS one, 14(4), e0214859. 2019
Survival of Mycobacterium bovis BCG oral vaccine during transit through a dynamic in vitro model simulating the upper gastrointestinal tract of badgers.
Williams, G. A., Koenen, M. E., Havenaar, R., Wheeler, P., Gowtage, S., Lesellier, S., & Chambers, M. A.

European Journal of Pharmaceutics and Biopharmaceutics, 136, 70‐83. 2019
In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration.
Butler, J., Hens, B., Vertzoni, M., Brouwers, J., Berben, P., Dressman, J., Andreas, C., Schaefer, K., Mann, J., McAllister, M., Jamei, M., Kostewicz, E., Kesisoglou, E., Langguth, P., Minekus, M., Mullertz, A., Schilderink, R., Koziolek, M., Jedamzik, P., Weitschies, W., Reppas C., Augustijns, P.

Molecular Pharmaceutics, 16 June, 2017
Gastrointestinal and Systemic Disposition of Diclofenac under Fasted and Fed State Conditions Supporting the Evaluation of in Vitro Predictive Tools.
Jens Van Den Abeele, Ronald Schilderink, Felix Schneider, Raf Mols, Mans Minekus, Werner Weitschies, Joachim Brouwers, Jan Tack and Patrick Augustijns.

International Journal of Pharmaceutics 498, 2016
Evaluation of two dynamic in vitro models simulating fasted and fed state conditions in the upper gastrointestinal tract (TIM-1 and tiny-TIM) for investigating the bioaccessibility of pharmaceutical compounds from oral dosage forms.
Miriam Verwei, Mans Minekus, Evelijn Zeijdner, Ronald Schilderink, Robert Havenaar

International Journal of Pharmaceutics, 29 July 2013
In vitro gastrointestinal model (TIM) with predictive power, even for infants and children
TNO, The Netherlands, Erasmus MC - Sophia Children's Hospital, Dept. of Clinical Pharmacy and Dept. of Pediatric Surgery and Intensive Care

The AAPS Journal, Vol. 14, No. 2, June 2012
An Investigation into the Utility of a Multi-compartmental, Dynamic,System of the Upper Gastrointestinal Tract to Support Formulation Development and Establish Bioequivalence of Poorly Soluble Drugs, Paul A. Dickinson, et al,
Clinical Science, AstraZeneca R&D, Alderley Park, Macclesfield, UKSK10 4TG., Pharmaceutical Development, AstraZeneca R&D, Alderley Park, Macclesfield, UK.


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