Ex vivo whole liver normothermic machine perfusion model

Prediction of First Pass Liver Effects, Biliary Excretion and DDI
●   Porcine Liver model (for contract research)
      > Hepatic Clearance
      > Hepatic Metabolism
      > Biliary Excretion
      > Plasma Exposure upon DDI
      > Dosing to portal vein and/or hepatic artery

●   Human Liver model (for collaboration research)
      > Hepatic Clearance
      > Hepatic Metabolism
      > Biliary Excretion
      > Plasma Exposure upon DDI
      > Dosing to portal vein and/or hepatic artery
      > NASH: Biomarker detection / Target Binding

  Download:
●   Normothermic Machine Perfusion of Diseased Explanted Livers to Study Hepatic Pharmacokinetic Processes (Poster at ISSX-2021)
●   Ex vivo whole liver perfusion model for prediction of drug drug interactions and biliary excretion of Rosuvastatin (Poster)
●   Pharmacokinetics Application of Normothermic Perfused Ex Vivo Porcine Livers. Poster ISSX-2019

Ex vivo Kidney perfusion model

TO STUDY RENAL CLEARANCE OF DRUGS
●  Experimental set up；
> Infusion of drug cocktail to study renal clearance of probe drug cocktail (0 - 120 min)
> Study DDI at the renal level by infusing probe + inhibitor cocktail mix (125- 245 min)
> Perfusate and urine drug profiles

●  Measurement；
      > Flow (pressure driven machine)
      > Inulin clearance
      > Urine production
      > Ad hoc viability analysis
        > Perfusate: pO2, pCO2, pH, sO2, ureum,creatinin, Na, K
      > Albumin (in perfusate and urine)
      > Biopsy: before, during & end of perfusion

Combined Liver and Kidney perfusion model

To study Clearance of Probe Drug Cocktail via Biliary and Renal Clearance route
●  Determine % of biliary and % renal excretion of drugs
●  Ability to perfuse for longer time
●  Open for Partnering